李博伟
李博伟,男,中国科学院烟台海岸带研究所研究员,本科毕业于厦门大学化学系;2009年毕业于中国科学院大连化学物理研究所,获得分析化学博士学位,导师为我国微流控领域创始人林炳承研究员;2009年至2011年受美国NIH项目资助于美国佛罗里达州立大学进行博士后研究工作。多年来一直从事微流控芯片实验室研究工作,主要包括基于微流控芯片平台的化学和生物学基础研究以及在环境监测、细胞药物分析、肿瘤标志物检测、现场即时检测食品安全等领域的应用。近年来在微流控芯片环境污染、疾病诊断研究方面取得重要进展,近年来以第一作者或通讯作者在 Angewandte Chemie International Edition、 Analytical Chemistry 、 Biosensors & Bioelectronics 、ACS Sensors等重要期刊发表论文。在已发表的50余篇论文中,中科院一区TOP期刊21篇,总影响因子230.3,总引用超1500余次,H-index=24,申请发明专利16项,已获得授权发明专利9项。主持国家自然科学基金面上项目和青年项目以及山东省自然科学基金重点项目、归国留学人员科研启动基金等项目。
部分期刊论文发表情况:(#为并列第一作者,*为通讯作者)
1. Bowei Li, Ji. Qi, Longwen Fu, Jinglong Han, Jaebum Choo*, Andrew J. deMello*, Bingcheng Lin, Lingxin Chen*. Integrated hand-powered centrifugation and paper-based diagnosis with blood-in/ answer-out capabilities. Biosensors & Bioelectronics, 2020, 165:112282. (中科院一区TOP, IF=10.257)
2.Jiawang Ding#,Bowei Li#, Lingxin Chen, Wei Qin*. A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing.Angewandte Chemie-International Edition, 2016, 55, 13033-13037. (中科院一区TOP, IF=12.959)
3. Ji. Qi#, Bowei Li#,*, Na Zhou, Xiaoyan Wang, Dongmei Deng, Liqiang Luo*, Lingxin Chen*. The strategy of antibody-free biomarker analysis by in-situ synthesized molecularly imprinted polymers on movable valve paper-based device. Biosensors & Bioelectronics, 2019, 142. (中科院一区TOP, IF=10.257)
4. Ji Qi, Bowei Li*, Xiaoyan Wang, Longwen Fu, Liqiang Luo*, Lingxin Chen*. Rotational Paper-Based Microfluidic-Chip Device for Multiplexed and Simultaneous Fluorescence Detection of Phenolic Pollutants Based on a Molecular-Imprinting Technique. Analytical Chemistry, 2018, 90, 11827-11834. (中科院一区TOP, IF=6.785)
5. Ping Liu#, Bowei Li#,*, Longwen Fu, Yan Huang, Mingsan Man, Ji Qi, Xiyan Sun, Qi Kang, Dazhong Shen*, Lingxin Chen*.Hybrid Three Dimensionally Printed Paper-Based Microfluidic Platform for Investigating a Cell's Apoptosis and Intracellular Cross-Talk. ACS Sensors, 2020, 5(2):464-473.(中科院一区TOP, IF=7.333)
6. Bowei Li, Lijuan Yu, Ji Qi, Longwen Fu, Peiqing Zhang, Lingxin Chen*. Controlling Capillary-Driven Fluid Transport in Paper-Based Microfluidic Devices Using a Movable Valve. Analytical Chemistry, 2017, 89, 5708-5713. (中科院一区TOP, IF=6.785)
7. Bowei Li, Zhong Zhang, Ji Qi, Na Zhou, Song Qin, Jaebum Choo, Lingxin Chen*. Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin. ACS Sensors, 2017, 2, 243-250. (中科院一区TOP, IF=7.333)
8. Ji Qi, Bowei Li*, Xinran Wang, Zhong Zhang, Zhuo Wang, Jinglong Han, Lingxin Chen*. Three-dimensional paper-based microfluidic chip device for multiplexed fluorescence detection of Cu2+ and Hg2+ ions based on ion imprinting technology. Sensors and Actuators B-Chemical, 2017, 251, 224-233. (中科院一区TOP, IF=7.10)
9. Dong Lin, Bowei Li*, Xiaofei Ji, Ji Qi, Wenhai Wang, Jinhua Li, Lingxin Chen*, Low cost fabrication of micro?uidic paper-based analytical devices with water-based polyurethane acrylate and their application for bacterial detection. Sensors and Actuators B-Chemical, 2020, 303: 127213.(中科院一区TOP, IF=7.10)
10. Junrui Zhou#, Bowei Li#,*, Anjin Qi, Yajun Shi, Ji Qi, Huizhong Xu*, Lingxin Chen*. ZnSe quantum dot based ion imprinting technology for fluorescence detecting cadmium and lead ions on a three-dimensional rotary paper-based microfluidic chip. Sensors and Actuators B-Chemical, 2020,305:127462(一区TOP, IF=7.10)
11. Xiange Sun, Bowei Li*, Anjin Qi, Chongguo Tian, Jinglong Han, Yajun Shi, Bingcheng Lin, Lingxin Chen*. Improved assessment of accuracy and performance using a rotational paper-based device for multiplexed detection of heavy metals. Talanta, 2018, 178, 426-431.(二区,IF=5.339)
12. Xiange Sun, Bowei Li*, Chunyuan Tian, Fabiao Yu, Na Zhou, Yinghua Zhan, Lingxin Chen*. Rotational paper-based electrochemiluminescence immunodevices for sensitive and multiplexed detection of cancer biomarkers. Analytica Chimica Acta, 2018, 1007, 33-39. (中科院一区TOP, IF=5.256)
13. Jinglong Han, Anjin Qi, Junrui Zhou, Guan Wang, Bowei Li*, Lingxin Chen*. Simple Way To Fabricate Novel Paper-Based Valves Using Plastic Comb Binding Spines. ACS Sensors, 2018, 3, 1789-1794. (中科院一区TOP, IF=7.333)
主持的基金项目:
1. 国家自然科学基金面上项目,41776110,基于微流控纸芯片分子印迹技术检测环境藻类毒素研究,2018/01-2021/12,67万,在研,主持。
2. 国家自然科学基金青年项目,21205131,集成式红外加热荧光定量PCR微流控芯片及其在病原体基因检测中的应用研究,2013/01-2015/12,25万,已结题,主持。
3. 山东省自然科学基金重点项目,ZR2020KB022,现代分析方法与面向活体的化学测量应用基础研究, 2021/01-2023/12, 30万,在研,主持。
4. 烟台科技发展计划,2015ZH087,基于分子印迹微流控纸芯片检测环境重金属污染物, 2015/01-2017/12,10万,已结题,主持。
科技奖励与荣誉称号:
1. 基于分子印迹材料的分子识别与传感分析,山东省高等学校优秀科研成果奖一等奖,山东省教育厅,2020年12月,第二完成人。
2. 海岸带环境典型重金属离子的快速分析与去除方法研究。 海洋工程科学技术奖二等奖, 中国海洋工程咨询协会, 2017年1月,第五完成人。
3. 基于分子印迹材料的样品前处理和传感分析,中国分析测试协会科学技术奖二等奖,中国分析测试协会,2017年10月,第四完成人。
招生方向:
1. 基于微流控芯片的环境污染物分析传感研究
2. 基于微流控芯片在生化分析检测中的应用
欢迎有分析化学、材料科学、环境化学、海洋化学、生物学等相关专业背景的同学报考。
联系方式:0535-2109133;E-mail: bwli@yic.ac.cn
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